Error analysis of idealized nanopore sequencing

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Error analysis of idealized nanopore sequencing.

This numerical study provides an error analysis of an idealized nanopore sequencing method in which ionic current measurements are used to sequence intact single-stranded DNA in the pore, while an enzyme controls DNA motion. Examples of systematic channel errors when more than one nucleotide affects the current amplitude are detailed, which if present will persist regardless of coverage. Absent...

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ژورنال

عنوان ژورنال: ELECTROPHORESIS

سال: 2013

ISSN: 0173-0835

DOI: 10.1002/elps.201300174